What is NAD+ ???

Nicotinamide Adenine Dinucleotide (NAD) is an essential ingredient in the metabolic process and reactions that occur in the cells within the human body. The NAD+ refers to the oxidized form of NAD. Coenzymes like NAD bind to our enzymes to help initiate and accelerate actions that are essential to our body’s healthy function. Some of those processes that are dependent on NAD are glycolysis (the breakdown of glucose into pyruvate and hydrogen), citric acid or tricarboxylic acid cycle (the release of stored energy from carbohydrates, proteins and fats through the oxidation of acetyl CoA), the oxidation or breakdown of fatty acids, DNA repair, inflammatory responses, among many other processes. [3][8]
Below are some of the many physiologic processes that are dependent upon NAD+

Immunity and Inflammation – research shows increased levels of inflammation when there are decreased levels of NAD+. NAD regulates immune function and inflammationand, protects against acute injury in kidney. Immune responses to stress, inflammation, or infections utilize nicotinamide adenine dinucleotide (NAD) resources through upregulation of NAD-dependent cellular repair enzymes.

Energy Metabolism – There are several metabolic pathways in the body. All of which require the presence of NAD+ function properly. A deficiency in NAD+ will impact all of the processes in the body negatively impact the effectiveness by which energy is generated and utilized in the body.

NAD+ increases energy by helping to deliver energy into the cells. This helps the body to improve and sustain athletic performance by boosting metabolism, energy levels and circulation. It also protects the muscles and assist in muscle recovery after high intensity work outs.

Circadian Clock – the circadian clock is the 24 hours internal clock in our brain that regulates cycles of alertness and sleepiness by responding to light changes in our environment. Levels of NAD + feed back into the clock to influence rhythmicity of biological function.  Decreased levels in NAD+ can disrupt our clock and result in daytime sleepiness, restlessness, and mood changes.

Cardiovascular Function – current human studies have shown that NAD+-boosting therapy can reduce mortality and provide moderate clinical benefits for patients with CAD. [5][1]NAD+ is essential in maintaining metabolic activity of the heart.

Kidney Function – As we get older, generally speaking, our renal function tend to decrease. Research indicates that NAD+ supplementation have increased protection against acute renal injury by stimulating the release of prostaglandin E2 which serves to improve renal function after an acute renal injury.

Liver function – normal levels of NAD+ levels in the body are essential for optimal function of the liver. Enzymes in NAD+ protect the liver from conditions such as hepatic fibrosis, nonalcoholic fatty liver disease, and toxic illnesses. It is shown to enhance ability to regenerate the liver and after a hepatic injury.

Neurologic Function – NAD+ has been shown to have a protective effect on the neurons in the brain after a significant neurological event such as a stroke and many other neurological diseases. Having normal levels of NAD+ in the body is essential to the normal functioning and survival of cerebral neurons. NAD+ has also shown to have benefits in treating diseases such as Alzheimer’s disease and recent findings have provided evidence that NAD+ may be a new target for reducing brain injuries and preventing ischemic brain injury.

The key benefits of NAD+ IV Therapy

NAD+ plays a crucial role in all the body’s major processes and therefore it is essential to ensure that NAD+ levels are optimal. If there are signs of NAD+ deficiency, such as in pellagra, which manifests as dermatitis, dementia, or diarrhea, supplemental IV NAD therapy may be warranted.[2] In addition to signs of NAD+ deficiency, there are other reasons for which an individual may consider receiving intravenous NAD+ supplementation; some of these reasons include the following:  

  1. Support addiction recovery
  2. Improves Symptoms Of PTSD, Anxiety, Depression And Fatigue
  3. Improves cognitive function
  4. Increase athletic performance
  5. Pain management
  6. Improve metabolic function


  1. Berge K. G., Canner P. L. (1991). Coronary drug project: experience with niacin. Coronary drug project research Group. Eur. J. Clin. Pharmacol. 40(Suppl. 1) S49–S51. 10.1007/BF03216290 [PubMed] [CrossRef] [Google Scholar]
  2. Benefits of NAD+ IV therapy. Benefits of NAD+ IV Therapy | Empower Pharmacy. (n.d.). Retrieved April 28, 2023, from
  1. Bockwoldt, M., Dorothée, H., Niere, M., Gossmann, T.I., Reinartz, I., Schug, A., Ziegler, M., Heiland, I., “Identification of evolutionary and kinetic drivers of NAD-dependent signaling”, Proceedings of the National Academy of Sciences of the United States of America, vol. 116 issue 32, pp. 15957-15966. Available:
  2. Brown G., Albers J. J., Fisher L. D., Schaefer S. M., Lin J. T., Kaplan C., et al. (1990). Regression of coronary artery disease as a result of intensive lipid-lowering therapy in men with high levels of apolipoprotein B. N. Engl. J. Med. 323 1289–1298. 10.1056/NEJM199011083231901 [PubMed] [CrossRef] [Google Scholar]
  3. Carlson L. A., Rosenhamer G. (1988). Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid.Acta Med. Scand. 223 405–418. 10.1111/j.0954-6820.1988.tb15891.x
  4. Landray M. J., Haynes R., Hopewell J. C., Parish S., Aung T., Tomson J., et al. (2014). Effects of extended-release niacin with laropiprant in high-risk patients. N. Engl. J. Med. 371 203–212. 10.1056/NEJMoa1300955 [PubMed] [CrossRef[Google Scholar]
  1. Navarro, M. N., Gómez de Las Heras, M. M., & Mittelbrunn, M. (2022). Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing. British journal of pharmacology179(9), 1839–1856.
  1. Xie, N., Zhang, L., Gao, W., Huang, C., Huber, P.E., Zhou, X., Li, C., Shen, G., Zou, Bingwen,” NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential”, Signal Transduction and Targeted Therapy. October 2020. Available:


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What is NAD+ ???

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Nicotinamide Adenine Dinucleotide (NAD) is an essential ingredient in the metabolic process and reactions that occur in the cells within the human body. The NAD+ refers to the oxidized form of NAD. Coenzymes like NAD bind to our enzymes to help initiate and accelerate actions that are essential to our body’s healthy function. Some of […]